影响慢性心力衰竭患者认知能力下降的发展和严重性的因素
Marius Militaru1,2,3, Daniel Florin Lighezan2,3,4, Cristina Tudoran5,6,7
1Department VIII, Neuroscience, Discipline of Neurology II, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
Medicina (Kaunas, Lithuania)
|November 27, 2024
概括
慢性心力衰竭 (CHF) 与认知能力下降 (CD) 有关. 患有心血管衰竭的患者表现出较低的认知分数和更多的抑郁症,年龄和血压等因素加剧了心血管衰竭.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 慢性心力衰竭 (CHF) 和认知衰退 (CD) 的流行率不断上升.
- 在受影响的患者中,CHF和CD之间的复杂相互作用.
- 需要了解指南定义的CHF与CD的神经心理评估之间的联系.
研究的目的:
- 研究慢性心力衰竭 (CHF) 和认知衰退 (CD) 之间的关联.
- 用标准化的神经心理学尺度评估患有和没有心血管疾病的患者的认知功能.
- 在被诊断为CHF的患者中识别CD的风险因素.
主要方法:
- 该研究包括190名高风险患者 (103人患有心血管衰竭,87人没有) 从2021年9月到2023年11月.
- 使用迷你精神状态评估 (MMSE) 和蒙特利尔认知评估 (MoCA) 评估认知功能.
- 统计分析包括相关性和多逻辑回归来确定风险因素.
主要成果:
- 与非CHF对照组相比,CHF患者的MMSE和MoCA得分明显较低.
- 在CHF患者中,每日活动减少和抑郁症严重程度增加.
- 左心室喷射分数 (LVEF) 与MMSE和NT-pro-BNP相关;年龄,血压,活动和抑郁症是心血管衰竭中CD的危险因素.
结论:
- 慢性心力衰竭患者表现出更高的认知能力下降的可能性.
- 在MMSE得分和LVEF之间存在直接关系,与NT-pro-BNP之间存在反向关系.
- 抑郁症和日常活动减少加剧了CHF患者的认知衰退.
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