在患有原发性Sjögren病的患者中对下丘脑-垂体-上腺轴的评估
Ana Glavina1,2, Petar Zurak3, Dinko Martinović4,5
1Department of Dental Medicine, University Hospital of Split, 21000 Split, Croatia.
Medicina (Kaunas, Lithuania)
|November 27, 2024
概括
患有原发性Sjögren病 (pSjD) 的患者表现出较高的下丘脑-垂体-上腺 (HPA) 轴活动,由升高的唾液皮质醇水平表明. 这种过度活跃与psjD患者的心理痛苦增加和口腔健康相关的生活质量降低相关.
科学领域:
- 内分泌学 在内分泌学.
- 自免疫性疾病 自免疫性疾病
- 心理神经免疫学 心理神经免疫学
背景情况:
- 主要Sjögren病 (pSjD) 是一种自身免疫性疾病,对下丘脑-垂体-上腺 (HPA) 轴有复杂的影响.
- 以前对PSJD患者的HPA轴活性进行的研究已经产生了不一致的结果.
研究的目的:
- 为了研究与健康对照组相比,pSjD患者的唾液皮质醇度.
- 评估pSjD中HPA轴的功能状态 (低活性或高活性).
主要方法:
- 一项涉及17名pSjD患者和17名对照对象的横截面研究.
- 使用刺激全唾液 (SWS) 和酶相关免疫吸收试验 (ELISA) 来测量唾液皮质醇度.
- 心理困扰 (抑郁,压力,焦虑) 和口腔健康影响 (OHIP) 用验证的问卷进行了评估.
主要成果:
- 与对照组相比,pSjD患者的唾液皮质醇度明显高 (p < 0.001).
- pSjD患者报告的抑郁,压力,焦虑和整体口腔健康影响的得分显著更高 (p <0.05).
- 该研究确定了唾液皮质醇 (>1.454) 的切断点,表明psjD中的HPA轴过活.
结论:
- 患有原发性Sjögren病的患者表现出HPA轴的短期过活.
- 在pSjD中,HPA轴活性升高与心理痛苦增加和与口腔健康相关的生活质量降低有关.
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