适当的过敏性鼻炎药物可以减少全身类固醇的需求,并预防鼻炎
Min Kwang Byun1, Won Jin Yang1, Yong Jun Choi1
1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.
Journal of clinical medicine
|November 27, 2024
概括
鼻内皮质类固醇 (INCS) 减少了对过敏性鼻炎 (AR) 的全身类固醇需求. 诸如INCS,抗组胺药物 (AH) 和AH-Leukotriene受体对抗剂 (AH-LTRA) 等药物有助于预防AR患者的鼻炎.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 过敏性鼻炎 (AR) 是一种普遍的疾病,通常需要全身类固醇.
- 肺炎可以与COVID-19,鼻炎和喘同时发生.
- 需要真实世界的数据来比较AR药物的有效性.
研究的目的:
- 为了比较不同过敏性鼻炎 (AR) 药物的临床结果.
- 评估AR治疗对全身类固醇使用和鼻炎发病率的影响.
- 为了分析AR治疗预后的现实世界数据.
主要方法:
- 利用了来自韩国国民健康保险服务的国家索赔数据.
- 包括275,895名在2018-2018年新确诊AR的成年患者.
- 根据AR药物类型将患者分为五组,并分析了3年的随访数据.
主要成果:
- 内皮质类固醇 (INCS) 用户的系统性类固醇需求明显降低 (HR 0.503,p < 0.001).
- 与其他AR药物相比,INCS中鼻炎的发病率较低 (6-8%) (约为1. 这是11%的11%).
- 与其他AR药物相比,抗组胺剂 (AH),AH-Leukotriene受体对抗剂 (AH-LTRA) 和INCS显著降低了鼻炎风险.
结论:
- 在过敏性鼻炎中,INCS有效地减少了对全身类固醇的需求.
- AH,AH-LTRA和INCS显示出对鼻炎的保护作用.
- 选择适当的AR药物对于优化患者的临床结果至关重要.
关键词:
在 COVID-19 疫情中,过敏性鼻炎 过敏性鼻炎药物治疗 药物治疗鼻炎是指鼻炎的一种疾病.类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型: 类型:更多相关视频
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