系统性免疫炎症水平与Sjögren综合征患者眼睛干燥之间的关系
Ülkem Şen Uzeli1, Ayşe Gülşen Doğan2, Tayfun Şahin3
1Internal Medicine Department, Hitit University, Corum 19030, Turkey.
Journal of clinical medicine
|November 27, 2024
概括
这项研究发现,系统性免疫炎症指数 (SII) 和Sjögren综合征 (SS) 疾病活动之间存在强烈联系. 在患者中,较高的SII水平与增加的SS严重程度和干眼症状相关.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 眼科医生 眼科 眼科
背景情况:
- 斯约格伦综合征 (SS) 是一种慢性自身免疫性疾病,其特征是炎症.
- 眼睛干燥和口腔干燥几乎影响了所有患有初级SS (pSS) 的患者.
- 炎症过程是SS病变的关键.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与pSS患者的疾病活性之间的相关性.
- 评估SII与pSS干眼参与之间的关系.
- 评估pSS患者的血液学参数.
主要方法:
- 一项涉及28名女性pSS患者 (18-65岁) 的横截面研究.
- 用于评估疾病活动的Sjögren综合征疾病活动指数 (ESSDAI) 计算.
- 使用了施密尔测试和眼部表面疾病指数 (OSDI) 来评估干眼.
主要成果:
- 在SII水平和pSS疾病活性之间观察到强烈的正相关性.
- 施尔默测试显示,与眼睛干燥时间的负相关性,表明眼睛干燥.
- 在SII和OSDI分数之间发现了正相关性.
结论:
- 血液学参数,包括SII,与pSS中干眼的发展相关.
- 中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和SII在pSS患者中显示出显著的变化.
- 在Sjögren综合征中,SII可以作为疾病活动和干眼的有价值指标.
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