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结核病和炎症性心肌病:探索心肠轴
Lucia Ilaria Birtolo1, Gianluca Di Pietro1, Riccardo Improta1
1Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, "Policlinico Umberto I" Hospital, Viale del Policlinico, 155, 00161 Rome, Italy.
Journal of clinical medicine
|November 27, 2024
概括
结核病 (CD) 增加了心血管风险,特别是炎症性心脏病,如心肌炎和心周炎. 无质饮食有效地治疗了大多数患者,解决了症状并恢复了心脏功能.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 自体免疫学 自体免疫学
背景情况:
- 病 (CD) 与心血管 (CV) 事件的发病率较高有关.
- 炎症性心脏病,如心周炎和心肌炎,与CD特别相关.
- 这种关联背后的病理生理机制需要进一步研究.
研究的目的:
- 综合现有证据,关于乳病和炎症性心血管疾病之间的关联.
- 调查患有CD和炎症性心脏病的患者的患病率和长期结果.
- 探索底层的自身免疫机制,将CD连接到心膜炎和心肌炎.
主要方法:
- 在PubMed,Scopus和谷歌学者中进行了系统的文献搜索.
- 纳入了研究,重点关注患有炎症性心血管疾病的CD患者的患病率和结果.
- 来自案例系列,案例报告和观察性研究的数据被评估.
主要成果:
- 分析了10项涉及22名患者 (9名女性,13名男性) 的研究.
- 六名患者出现了复发性心周炎,16名患者患有与腹膜炎相关的心肌炎.
- 无质饮食 (GFD) 在87.5%的病例中是有效的,心周炎的症状完全消失,81%的心肌炎病例的功能恢复.
结论:
- 肌心炎和心膜炎,特别是复发形式,可以是儿童和成人群体中病的并发症.
- 针对心脏和小肠的自身免疫反应与这些疾病有关.
- 早期诊断和管理GFD对于改善受影响个体的结果至关重要.
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