接受抗逆转录病毒治疗的HIV成年人体重增加:目前的知识和未来的前景
Konstantinos Markakis1, Olga Tsachouridou1, Eleni Georgianou1
1Infectious Diseases Division, 1st Internal Medicine Department, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Life (Basel, Switzerland)
|November 27, 2024
概括
高活性抗逆转录病毒疗法 (HAART) 对艾滋病毒感染者 (PLWH) 的体重产生影响. 较新的整合酶链转移抑制剂 (INSTIs) 结合二甲胺烟酸 (TAF) 可能会比较旧的疗法增加更多的体重.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 身体重量受到宿主,环境和HIV感染者 (PLWH) 的疾病特异性因素的影响.
- 艾滋病毒疾病的进展可能导致消耗综合征,这是可逆的高活性抗逆转录病毒疗法 (HAART).
- 在临床试验中观察到的体重变化根据特定的抗逆转录病毒疗法 (ART) 方案有显著差异.
研究的目的:
- 审查接受HAART的PLWH的体重变化.
- 探索与HAART相关的体重变化背后的致病机制.
- 批判性地评估当前的数据和挑战,以评估HAART在体重管理中的作用.
主要方法:
- 对最近关于PLWH在HAART上的体重变化研究的文献综述.
- 对数据进行分析,比较不同的ART疗法,重点关注整合酶链转移抑制剂 (INSTIs) 和tenofovir配方.
- 检查与体重增加或减轻相关的潜在致病机制.
主要成果:
- 整合酶链转移抑制剂 (INSTIs),特别是与诺福维尔胺胺酸盐 (TAF) 联合使用时,与含有诺福维尔胺酸盐 (TDF) 的疗法相比,与更大的体重增加有关.
- 诺福维尔二醇烟酸 (TDF) 似乎对体重增加有减弱作用.
- 最近的数据表明,在做出关于体重影响的HAART治疗决定时,需要采取更谨慎的方法.
结论:
- 治疗疗法,特别是包括INSTI和TAF在内的疗法,对PLWH患者的体重有很大影响.
- 了解体重变化背后的机制对于优化HAART至关重要.
- 需要对数据进行进一步的批判性评估,以指导对ART启动和切换的临床决策,同时考虑体重管理.
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