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血清Malondialdehyde-modified低密度脂蛋白水平可能是与大动脉硬相关的生物标志物,在接受腹腔透析的患者中
Yu-Chi Chang1, Chih-Hsien Wang1,2, Chi-Chong Tang1,3
1Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
Life (Basel, Switzerland)
|November 27, 2024
概括
血清中有氧化低密度脂蛋白 (MDA-oxLDL) 预测腹膜透析患者的大动脉硬. 较高的MDA-oxLDL水平与心血管疾病风险增加相关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 生物化学 生物化学
背景情况:
- 血清中有氧化低密度脂蛋白 (MDA-oxLDL) 与动脉样硬化和心血管疾病 (CVD) 的风险有关.
- 血管化和动脉硬性在经过腹膜透析 (PD) 的患者中很常见.
研究的目的:
- 为了研究大动脉硬与患有PD的患者的MDA-oxLDL水平之间的联系.
- 为了确定MDA-oxLDL是否可以在这个人群中作为大动脉硬的预测因素.
主要方法:
- 一项涉及92名PD患者的横截面研究.
- 用袖口式体积位移来评估大动脉硬度 (cfPWV>10 m/s) 测量的带关节脉冲波速率 (cfPWV).
- 血清MDA-oxLDL水平通过酶相关免疫吸收试验量化.
主要成果:
- 35.9%的患者表现出大动脉硬.
- 患有大动脉硬度的患者有显著更高的静脉血压,甘油三,C反应蛋白,年龄,体重,BMI,腰围,MDA-oxLDL水平和糖尿病患病率.
- 多变量分析确定了MDA-oxLDL水平,BMI和SBP作为大动脉硬的重要预测因素.
- 血清MDA-oxLDL是一种cfPWV的独立预测剂.
结论:
- 血清MDA-oxLDL水平与cfPWV有正相关性.
- 在PD患者中,MDA-oxLDL可以预测大动脉硬性.
- MDA-oxLDL可能是评估PD患者心血管疾病风险的有价值标志物.
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