在COVID-19患者中评估内皮功能,使用外周动脉度计
Athanasios Moulias1, Rafail Koros1, Angeliki Papageorgiou1,2
1Department of Cardiology, General University Hospital of Patras, 26504 Patras, Greece.
Life (Basel, Switzerland)
|November 27, 2024
概括
COVID-19显著损害了内皮功能,通过降低高血压血管响应指数 (LnRHI) 表示. 这种功能障碍在出院后至少持续六个月,突出显示了长期的血管健康问题.
科学领域:
- 心血管研究研究心血管研究
- 传染性疾病 传染性疾病
- 血管生物学 血管生物学
背景情况:
- COVID-19越来越多地与内皮功能障碍有关,可能导致血栓和心血管问题.
- 内皮功能评估对于了解COVID-19后的并发症至关重要.
研究的目的:
- 为了评估COVID-19幸存者的内皮功能,使用外围动脉度计 (EndoPAT).
- 为了确定内皮功能障碍的持续性及其与临床结果的关联.
主要方法:
- 用外围动脉度计 (EndoPAT) 来测量高血压血管响应指数 (LnRHI).
- 一组23名COVID-19患者与22名匹配的对照组进行了比较.
- 在住院期间进行测量,在住院两个月后,在出院六个月后进行测量.
主要成果:
- 与对照组相比,COVID-19患者在出院两个月后显著降低了LnRHI (p=0.012).
- 在住院期间,内皮功能存在这种差异,并在六个月内持续存在.
- 高比例的COVID-19患者 (61%在住院期间,55%在六个月后) 呈现出内皮功能障碍 (LnRHI ≤0.51).
结论:
- COVID-19对内皮功能产生不利影响,由LnRHI持续减少证明.
- 内皮功能障碍在COVID-19幸存者中很常见,可能会长期存在.
- 虽然观察到内皮功能障碍,但在这个队列中没有发现血栓事件,心血管并发症或死亡率的显著差异.
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