基因变异和严重抑郁症:一个系统的审查
Larissa Sousa Silva Bonasser1, Calliandra Maria de Souza Silva2, Caroline Ferreira Fratelli3
1Postgraduate Program in Health Sciences, University Campus Darcy Ribeiro, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 70910-900, Brazil.
Pharmaceuticals (Basel, Switzerland)
|November 27, 2024
概括
CYP2C19基因变异影响抗抑郁药代谢和主要抑郁障碍 (MDD) 治疗反应. 频率在全球范围内有所不同,影响临床特征和药物疗效,需要进一步研究个性化医疗.
科学领域:
- 药物基因组学 药物基因组学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 大型抑郁症 (MDD) 影响全球超过3亿人.
- 酶CYP2C19代谢各种抗抑郁药,影响治疗结果.
- 在CYP2C19的遗传变异可能会影响药物的疗效和患者的反应.
研究的目的:
- 系统地审查MDD群体中常见的CYP2C19基因变异的频率.
- 评估这些变体对MDD临床特征的影响.
- 评估CYP2C19变体对抗抑郁药治疗反应的影响.
主要方法:
- 按照PRISMA协议和PECOS战略进行系统审查.
- 在五个数据库中进行全面的文献搜索.
- 使用GRIPS和STROPS指南进行质量和偏见风险评估.
主要成果:
- 在不同人群中观察到CYP2C19多态度频率的显著变化.
- 一些研究将变异与MDD的发展,慢性和严重程度联系在一起,而另一些研究则没有发现任何关联.
- 这些变体影响了埃斯基塔洛普拉姆和西塔洛普拉姆的新陈代谢,但不影响塞特拉林,文拉法辛或布罗;治疗结果各不相同.
结论:
- CYP2C19遗传变异显示出特定人群的频率和与MDD不一致的关联.
- CYP2C19 变体对抗抑郁药物的有效性和耐受性的影响是药物依赖的,需要进一步研究.
- 澄清这些多态的作用对于优化MDD治疗策略至关重要.
相关概念视频
01:28Human Genetics
535
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
535
01:23Antidepressant Drugs: MAOIs and Other Agents
194
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
194
01:18Depression: Overview
216
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
216
01:27Depressive Disorders: MDD and Dysthymia
61
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
61
01:05Single Nucleotide Polymorphisms-SNPs
14.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
14.0K
01:30Bipolar Disorder
56
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
56