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益生菌和来自大米的化合物组合减轻了结肠炎的严重程度

Ashraf Khalifa1,2, Mayyadah Abdullah Alkuwayti1, Basem M Abdallah1

  • 1Biological Science Department, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa 31982, Saudi Arabia.

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概括

乳腺肠杆菌 (Enterococcus lactis) 补充剂在治疗大肠炎,减少炎症和改善肠道健康方面显示出前景. 将其与哈萨维大米蛋白溶解酸结合,可以增强这些治疗效果,以更好地治疗结肠炎.

关键词:
阿尔-阿斯法尔湖 (Al-Asfar Lake) 是一个大湖.乳腺肠球菌 (Enterococcus lactis) 是一个细菌.哈萨维的米饭是哈萨维的米饭.炎症性疾病 炎症性疾病蛋白质解蛋白质解蛋白质解蛋白质

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科学领域:

  • 微生物学 微生物学
  • 胃肠病学 胃肠病学
  • 免疫学 免疫学 免疫学

背景情况:

  • 结肠炎,以结肠炎症为特征,需要新的治疗策略.
  • 硫酸德克斯 (DSS) 是小鼠实验性结肠炎的常见诱导物.
  • 探索用于结肠炎管理的天然化合物和益生菌是一个活跃的研究领域.

研究的目的:

  • 在DSS诱导的大肠炎的小鼠模型中研究Enterococcus lactis (E. lactis) 和哈萨维大米蛋白溶解酸 (HPL) 的治疗潜力.
  • 评估E. lactis和HPL对大肠炎参数的综合影响.
  • 评估这些治疗对肠道透性,氧化应激和炎症标志物的影响.

主要方法:

  • 在雄性小鼠中,使用DSS诱导大肠炎.
  • 在小鼠中补充了E. lactis和/或HPL.
  • 测量了疾病活动指数 (DAI),肠道透性 (FITC-dextran) 和结肠超氧化物失变酶 (SOD) 活性.
  • 分析了亲炎性标记物和与细胞死亡相关的蛋白质水平.

主要成果:

  • 补充E. lactis显著改善了在DSS诱导的大肠炎中DAI得分和肠道透性.
  • 与单独使用E. lactis相比,E. lactis和HPL的组合显示出更高的疗效.
  • 这两种治疗都增加了SOD活性,表明氧化应激减少.
  • 促炎性标志物和与细胞死亡相关的蛋白质 (PCNA,PTEN,VEGF,COX-2,STAT-3) 显著减少.

结论:

  • 乳腺肠球菌 (Enterococcus lactis) 对大肠炎具有显著的治疗益处.
  • 哈萨维大米蛋白质溶解酸可能会提高E. lactis在结肠炎治疗中的有效性.
  • 这种组合疗法需要进一步研究,以便在治疗炎症性肠道疾病方面获得临床应用.