冷干燥作为一种多功能过程在改善医疗用水凝性能方面的作用
Kacper Odziomek1, Anna K Drabczyk1, Paulina Kościelniak2
1Cracow University of Technology, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry and Technology, 24 Warszawska Street, 31155 Cracow, Poland.
Pharmaceuticals (Basel, Switzerland)
|November 27, 2024
概括
冷干燥增强了基酸盐/聚乙烯醇) 水凝,改善了它们在药物输送和伤口愈合应用中的性能. 这些冷干燥的水凝表现出更好的稳定性和受控的药物释放,显示出作为医疗包裹的巨大商业潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 制药科学 制药科学
背景情况:
- 冷干燥 (冷化) 是一种用于保存药物,疫苗和生物制品的方法.
- 它的应用正在扩大,以增强新型药物和载体,如用于药物输送和伤口愈合的水凝.
- 基于基酸盐/聚乙烯醇的水凝被广泛研究用于医学应用.
研究的目的:
- 调查冷干燥在改善基酸盐/聚乙烯醇基水凝的物理化学性能方面的多功能作用.
- 评估这些水凝对于医疗应用的适用性,包括药物输送和伤口愈合.
主要方法:
- 通过化学交叉连接制备水凝,然后冷干燥.
- 描述包括凝分数,胀率,FT-IR,SEM,TG/DTG,体外药物释放和细胞毒性测试.
- 使用Korsmeyer-Peppas模型分析了药物释放动力学.
主要成果:
- 冷干燥增加了水凝的凝分数和热稳定性.
- 胀取决于pH值 (175-282%),孔隙大小在1.07至1.74微米之间.
- 观察到受控的,延长的体外药物释放 (例如,在pH值为9.0的96小时后63%的酸,73%的氨酸).
- 水凝对人体纤维细胞无毒性 (>48小时后90%的活力).
结论:
- 冷干燥显著改善了基酸盐/聚乙烯醇) 水凝的物理化学性能.
- 增强的水凝显示出控制药物输送和伤口愈合的潜力.
- 这些发现支持将这些水凝作为先进的医疗包裹商业化.
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