通过冷干燥使用QbD方法制备含有布洛芬的可吸入的γCD-MOFs
Anett Motzwickler-Németh1, Petra Party1, Péter Simon2
1Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, 6720 Szeged, Hungary.
Pharmaceutics
|November 27, 2024
概括
这项研究引入了一种新的冷干燥方法,用于创建基于循环烯的金属有机框架 (CD-MOF),装有布洛芬用于肺部输送. 开发的CD-MOF显示了治疗囊性纤维化症的潜力,改善了药物的溶解性和溶解性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 制药科学 制药科学
背景情况:
- 基于环氧的金属有机框架 (CD-MOF) 是一种新兴材料,具有药物输送潜力.
- 对CD-MOF的研究,特别是用于肺部的应用,仍处于早期阶段.
- 开发有效的CD-MOF制备方法对于其临床转化至关重要.
研究的目的:
- 开发一种新的冷干燥方法,用于制备基于玛环氧德 (γCD) 的金属有机框架 (MOF).
- 在 γCD-MOF 中封装易布洛芬 (IBU),一种水溶性较差的药物,用于潜在的囊性纤维化治疗.
- 为了优化可吸入的γCD-MOF/IBU配方的制备,具有理想的空气动力学特性.
主要方法:
- 实验的设计采用了设计质量 (QbD) 原则和LeanQbD®软件.
- 优化了IBU与 γCD 摩尔比率,化时间和有机溶剂百分比等关键因素.
- 鉴定包括显微镜 (SEM),粒子大小分析,DSC,XRPD,FT-IR和NMR光谱.
主要成果:
- 通过冷干燥方法成功地产生了γCD-MOF/IBU复合体.
- 最佳配方实现了高细颗粒分数 (FPF%) 的38.10±5.06%和47.18±4.18%.
- γCD-MOF/IBU配方表现出快速溶解的特征,并增强了IBU的溶解性.
结论:
- 冷干燥是一种有效和创新的方法,用于生产可吸入的gCD-MOF,用于输送布洛芬.
- 实现的颗粒大小修改对于成功的肺药物摄入至关重要.
- 这些γCD-MOF配方需要进一步研究,作为肺部疾病的先进药物输送系统.
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