评估新型联合加工辅助剂的潜力,使其能够直接压缩和修改释放布洛芬
Ivana Aleksić1, Teodora Glišić1, Slobodanka Ćirin-Varađan1
1Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Pharmaceutics
|November 27, 2024
概括
新型基于脂质的联合加工辅助剂为直接可压缩的修饰释放片提供了有希望的解决方案. 这些辅助剂提高了流动性和机械性能,即使含有较高的布洛芬含量,也简化了药片制造.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
背景情况:
- 现代平板电脑打印机需要高性能辅助剂来提高生产率.
- 需要适合修改释放配方的可直接压缩的辅助剂.
- 联合加工是开发先进辅助剂系统的可行策略.
研究的目的:
- 研究用于制造含有布洛芬的修饰释放片的新型辅助剂.
- 评估基于脂质的联合加工辅助剂在直接可压缩配方中的潜力.
- 评估配方变量对压缩行为和药物释放的影响.
主要方法:
- 使用了乳糖单水合物与甘棕酸的溶解颗粒化.
- 分析了粘合剂颗粒大小,易布洛芬含量,压缩压力和速度的影响.
- 评估了压缩行为,机械性能和药物释放概况.
主要成果:
- 同处理的辅助剂表现出良好的流动性和平板电脑机械性能,最高可达70%的布洛芬.
- 基于脂质的辅助剂促进了直接压缩,没有额外的滑剂,用于高剂量的粘合剂API.
- 药片在10小时内呈现出延长的布洛芬释放,压缩速度对拉伸强度的影响最小.
结论:
- 新型基于脂质的联合加工辅助剂显示出直接可压缩的修饰释放配方的巨大潜力.
- 这些辅助剂适用于高剂量,具有挑战性的活性药物成分,如ibuprofen.
- 开发的辅助剂通过消除对滑剂的需求来简化制造过程.
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