抗结核活动的7-Methyljuglone-Loaded多- ((乳酸合糖化物) 纳米颗粒的抗结核活动
Bianca Diedericks1, Anna-Mari Kok1,2, Vusani Mandiwana3
1Department of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa.
Pharmaceutics
|November 27, 2024
概括
装有7-甲基隆 (7-MJ) 的聚乳糖合糖酸 (PLGA) 纳米颗粒显示出细胞毒性降低和改善结核病 (TB) 治疗的潜力. 这些纳米粒子被细胞有效地吸收,这表明药物输送系统的前景.
科学领域:
- 自然产品药物输送天然产品药物输送
- 纳米医学用于传染病.
- 基于聚合物的药物载体.
背景情况:
- 自然产品正在探索用于治疗诸如结核病 (TB) 等疾病.
- 聚--乳酸-同-葡萄糖) 酸 (PLGA) 纳米粒子作为药物输送系统正在被研究.
- 研究了来自*Euclea natalensis*的化合物7-甲基隆 (7-MJ).
研究的目的:
- 为了研究PLGA纳米颗粒加载7-甲基隆 (7-MJ) 的使用.
- 评估7-MJ及其PLGA纳米粒子的抗菌和细胞毒性作用.
- 为了评估7-MJ PLGA纳米颗粒的细胞吸收.
主要方法:
- 对 *Mycobacterium smegmatis* 和 *Mycobacterium tuberculosis* (对药物敏感和MDR) 的抗菌活性测试.
- 使用差异化U937细胞进行细胞毒性评估.
- 吞研究以确定U937细胞的纳米粒子吸收.
主要成果:
- 7-MJ表现出抗菌菌活性,MIC值为1.6微克/毫升和0.4微克/毫升.
- 免费的7-MJ对U937细胞表现出细胞毒性 (IC50为3.25μg/mL).
- 7-MJ PLGA纳米颗粒的细胞毒性降低了80倍,并被U937细胞吸收.
结论:
- PLGA纳米颗粒提供了一个潜在的策略来降低7-MJ的细胞毒性.
- 这项研究表明,使用PLGA纳米粒子改善了结核病治疗的交付可能性.
- 纳米粒子配方增强了天然产品的治疗潜力.
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