快速多距离时间域NIRS和DCS系统用于临床应用
Marco Nabacino1, Caterina Amendola1, Davide Contini1
1Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy.
Sensors (Basel, Switzerland)
|November 27, 2024
概括
我们开发了一种增强的时间域近红外光谱 (TD NIRS) 和扩散相关光谱 (DCS) 系统,以提高深度灵敏度和在组织中快速血液动力学监测. 使用幻象和体内实验证实了系统验证.
科学领域:
- 生物医学光学 生物医学光学
- 医疗器械 医疗器械 医疗器械
- 生理监测 生理监测
背景情况:
- 精确测量组织血液动力学对于理解生理过程和诊断疾病至关重要.
- 现有的系统往往缺乏深度灵敏度或监测快速血液动力学变化的能力.
- 时间域近红外光谱学 (TD NIRS) 和扩散相关光谱学 (DCS) 提供了关于组织光学特性和血液流动的补充信息.
研究的目的:
- 设计和建造一个集成TD NIRS和DCS的先进的双模式系统.
- 通过使用双源探测器距离,提高分层组织的深度灵敏度.
- 为了实现高速采集,用于监测快速的血液动力学振荡.
主要方法:
- 该系统包含两个独立的通道,用于同时采集TD NIRS和DCS.
- 使用OEM的TD NIRS设备,用于测量飞行时间的稳定光子分布.
- 采用时间标记器和软件相关器,用于灵活的DCS信号处理.
- 具有用户友好的GUI,用于数据采集和在线分析.
主要成果:
- 根据标准化的协议,对校准的组织幽灵进行了系统表征.
- 证明了稳定和强大的TD NIRS和DCS信号的获取.
- 通过在休息和血管封闭期间的体内测量成功验证了系统.
结论:
- 开发的集成TD NIRS和DCS系统为组织光学和血液动力监测提供了更好的性能.
- 该系统的双通道设计和快速采集能力提高了深度灵敏度和动态范围.
- 用幻影和体内研究的验证证实了其适用于现实世界生物医学应用的适用性.
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