肠道和肺部微生物组之间的有趣联系
Magdalena Druszczynska1, Beata Sadowska1, Jakub Kulesza2
1Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, Institute of Microbiology, Biotechnology and Immunology, University of Lodz, 90-237 Lodz, Poland.
Pathogens (Basel, Switzerland)
|November 27, 2024
概括
肠-肺轴是肠和肺之间的通讯通道,显著影响呼吸系统健康和免疫反应. 了解这种联系为呼吸系统疾病提供了新的治疗点.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 肠-肺轴描述了肠和肺之间的双向通信.
- 这个轴涉及免疫相互作用,微生物群落和代谢副产品.
- 来自肠道的信号影响呼吸功能和疾病易感性.
研究的目的:
- 系统地审查关于肠肺轴的文献.
- 了解肠道微生物在呼吸系统健康和疾病中的作用.
- 探索针对微生物群的呼吸道疾病的治疗策略.
主要方法:
- 2001-2024年研究的系统审查.
- 关键词:"肠肺轴"",微生物组"",呼吸系统疾病"",免疫信号".
- 研究选择基于肠肺沟通,失生症和微生物群在呼吸系统疾病中的作用的相关性.
主要成果:
- 肠肺轴对于调节免疫反应和维持呼吸系统健康至关重要.
- 肠道微生物群影响肺部的炎症和免疫反应.
- 最近的研究 (2020-2024) 显著有助于理解这一轴.
结论:
- 肠肺轴是呼吸系统健康的重要途径.
- 准肠道微生物群为喘和COPD等呼吸道疾病提供了潜在的治疗干预措施.
- 对肠肺轴的进一步研究可以增强呼吸医学中的预防和治疗方法.
相关概念视频
Anatomy of the Intestines
71.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.4K
Bacterial Flora of the Large Intestine
385
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
385
What is Monogastric Digestion?
70.6K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.6K
Gross Anatomy of the Lungs
1.6K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
1.6K
Physiology of Enteric Nervous System and Gut Health
228
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
228


