临床相关的动物感染病原体的抗菌耐药性概况 世卫组织优先病原体
Elaine Meade1, Mark Anthony Slattery2, Mary Garvey1,3
1Department of Life Science, Atlantic Technological University, F91 YW50 Sligo, Ireland.
Pathogens (Basel, Switzerland)
|November 27, 2024
概括
伴侣动物有抗生素耐药的细菌和真菌,构成动物传播的风险. 这项研究强调了这些病原体令人担忧的抗微生物耐药性,强调了对抗传染病的一种健康方法的必要性.
科学领域:
- * 一个健康和动物传染病研究.
- * 在兽医中抗菌素耐药性 (AMR)
- * 公共卫生微生物学
背景情况:
- *世界卫生组织确定了具有高抗菌素耐药性的关键细菌和真菌病原体.
- *ESKAPE病原体 (菌杆菌,金黄色葡萄球菌,肺炎菌,宝曼尼菌,Pseudomonas aeruginosa和肠杆菌物种) 导致显著的发病率和死亡率.
- *伴侣动物可以携带动物传染病原体,将动物健康与人类传染病联系起来.
研究的目的:
- *从伴侣动物中分离出来的动物性细菌和真菌病原体中研究抗菌素耐药性模式.
- * 评估伴侣动物作为抗生素耐药生物体的储存库的潜力.
- * 探索抗菌素耐药性和优先病原体中的特定遗传标记之间的关系.
主要方法:
- *从动物病例中分离和识别细菌和真菌病原体.
- *使用磁盘扩散和最小抑制度 (MIC) 测试进行体外抗菌敏感性测试.
- * 对抗微生物耐药性基因的基因查,包括扩展光谱β-乳糖酶 (ESBL) 生产.
主要成果:
- * 在关键的细菌病原体中观察到高水平的多药性耐药性,包括大肠杆菌,Klebsiella pneumoniae,Acinetobacter baumannii和Pseudomonas aeruginosa.
- * 在关键优先细菌中发现多药耐药性和ESBL产生之间存在显著的关联.
- *真菌分离物表现出显著的耐药性,安福特里辛B在测试的抗真菌药物中表现出最一致的有效性.
结论:
- *伴侣动物作为抗生素耐药性病原体和耐药性基因的储存库,促进动物传播.
- *在来自动物的临床相关病原体中AMR的患病率是一个重大的公共卫生问题.
- * 调查结果强调,需要整合"一健康"战略,以缓解抗菌素耐药性的传播.
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