在先天性细胞大脑病毒感染中,听觉和静脉的参与
Swetha G Pinninti1, William J Britt1,2,3, Suresh B Boppana1,2
1Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Pathogens (Basel, Switzerland)
|November 27, 2024
概括
先天性细胞大脑病毒 (cCMV) 经常导致感觉神经听力损失和发育问题. 在cCMV中,静脉功能缺陷也很常见,影响神经发育,但仍未得到充分研究.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 遗传性细胞大脑病毒 (cCMV) 是儿童非遗传性神经感官听力损失 (SNHL) 的主要原因.
- cCMV与显著的发育障碍和被低估的前体缺陷 (VI) 发病率有关.
- 在cCMV中SNHL和VI的发病包括直接的病毒效应和炎症反应.
研究的目的:
- 总结当前关于cCMV儿童听觉和前立腺疾病自然史和病原学的知识.
- 突出了cCMV中VI的低估和潜在影响.
- 讨论cCMV中SNHL的可变表现和进展.
主要方法:
- 审查关于cCMV,SNHL和VI的当前文献.
- 对cCMV中听觉和前庭功能障碍的自然史和病变发生现有数据的分析.
- 综合了有关这些疾病临床表现和进展的发现.
主要成果:
- cCMV对儿童听力损失作出了重大贡献,SNHL的严重程度,发病和进展各不相同.
- 越来越多的人认为,在cCMV中,静脉功能缺陷 (VI) 越来越频繁,并且与不良的神经发育结果有关.
- 新生儿听力查可能会错过许多cCMV相关的SNHL病例,原因是发病迟或特征波动.
结论:
- cCMV是儿科SNHL和VI的关键因素,需要进一步研究其自然史和病变.
- 与cCMV相关的听觉和前体缺陷的可变性强调了当前查方法的局限性.
- 了解cCMV影响的全部范围对于及时诊断和干预以改善神经发育结果至关重要.
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