在现场生成二氧化气体的方法,用于自动化化器的灭菌
Cédric Schicklin1, Georg Rauter1, Philippe Claude Cattin2
1Bio-Inspired RObots for MEDicine-Laboratory, Department of Biomedical Engineering, University of Basel, 4123 Allschwil, Switzerland.
Pathogens (Basel, Switzerland)
|November 27, 2024
概括
自动化化器灭菌对于制药研究至关重要. 气态二氧化物 (gClO2) 通过使用粉末片在环境温度下有效消毒化器,保护敏感设备.
科学领域:
- 微生物学和灭菌技术
- 科学研究中的自动化.
背景情况:
- 化器中的微生物污染破坏了自动化药物临床前测试.
- 当前的灭菌方法,如蒸汽,需要高温,与自动化系统不兼容.
研究的目的:
- 为了证明二氧化气体 (gClO2) 在自动化化器灭菌中的有效性.
- 评估从固体粉末片中产生的gClO2作为一种可行的环境温度灭菌方法.
主要方法:
- 选择的代表性微生物:细菌 (Bacillus subtilis),真菌 (Saccharomyces cerevisiae) 和T7菌体 (病毒).
- 在细胞培养化器内使用固体粉末片生成gClO2.
- 评估了30个周期的灭菌效率和对化器传感器和执行器的影响.
主要成果:
- gClO2有效地在15分钟内消除了细菌,真菌和病毒代理.
- 在30个灭菌周期后,化器的传感器和执行器仍然能正常工作.
- 在没有专门的设备的情况下实现了gClO2生成.
结论:
- 从粉末片中生成的gClO2为化器提供了一种高效的环境温度灭菌解决方案.
- 该方法与自动化系统兼容,可保护敏感部件.
- 这种方法广泛适用于化器和医疗机器人的现场灭菌.
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