脂肪细胞FGF21信号缺陷加剧脂肪组织炎症在孕期糖尿病中
Lun Hua1,2,3, Yi Yang1,2,3, Haoqi Zhang1,2,3
1Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China.
Nutrients
|November 27, 2024
概括
纤维细胞生长因子21 (FGF21) 信号障碍使妊娠糖尿病 (GDM) 中的炎症和胰岛素抵抗恶化. 向FGF21可能通过调节脂肪组织炎症来为GDM提供新的治疗方法.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 孕期糖尿病 (GDM) 与脂肪组织炎症的增加有关.
- 纤维细胞生长因子21 (FGF21) 是一种代谢调节剂,在GDM中没有明确的作用.
- 了解FGF21在GDM中的功能对于开发新疗法至关重要.
研究的目的:
- 研究FGF21信号在脂肪组织炎症和GDM期间胰岛素抵抗中的作用.
- 阐明FGF21影响GDM免疫细胞分化和炎症的机制.
主要方法:
- 利用GDM的小鼠模型来评估白色脂肪组织中的FGF21信号.
- 研究了FGF21信号,炎症和胰岛素抵抗之间的相关性.
- 研究了FGF21对调控性T细胞 (Treg) 分化和PGE2合成的影响.
主要成果:
- 在GDM小鼠中,FGF21信号受损与脂肪组织炎症和胰岛素抵抗的增加相关.
- 怀孕诱导的脂肪细胞中的FGF21信号促进了Treg分化,减少了炎症.
- FGF21的抗炎作用可能涉及烯酸介导的PGE2合成.
结论:
- 在GDM中,FGF21信号传递在调节脂肪组织炎症和胰岛素敏感性方面发挥着至关重要的作用.
- FGF21调解脂肪细胞和免疫细胞之间的交叉声,影响GDM病理生理学.
- 准FGF21信号及其代谢物是GDM的潜在治疗策略.
更多相关视频
08:34Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
15.0K
06:50Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
Published on: August 16, 2020
2.6K
相关概念视频
01:22Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
01:20Pathophysiology of Diabetes
868
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
868
01:24Obesity
379
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
379