临床人群中酸盐补充剂的人体效能效应:系统审查和元分析
Cassandra C Derella1, Kara C Anderson2, Mary N Woessner3
1Department of Kinesiology, University of Virginia, Charlottesville, VA 22903, USA.
无机酸盐补充剂对心肺和代谢疾病 (CPMD) 患者的有氧性表现没有显著的人体效应. 虽然一些研究表明有好处,但分析表明由于异质性和小样本大小,影响微不足道.
科学领域:
- 运动生理学 运动生理学
- 营养科学 营养科学
- 心血管健康 心血管健康
背景情况:
- 无机酸盐 (NO3-) 补充剂正在通过氧化 (NO) 转化探索人体效益潜力.
- 减少的NO生物可用性是许多心肺和代谢疾病 (CPMD) 的特征,这表明NO的潜在益处3-.
- 本综述评估了NO3-补充剂在CPMD群体中的人体效应.
研究的目的:
- 系统地审查和元分析无机酸盐补充剂对CPMD患者有氧运动结果的人体效应.
主要方法:
- 系统搜索随机,安慰剂控制的交叉试验,直到2023年12月.
- 纳入标准侧重于CPMD群体中有氧运动结果变量.
- 对22项纳入研究的数据进行了元分析.
主要成果:
- 46%的单个研究报告了无机酸盐补充剂对人体效益的益处.
- 后分析显示,对最大或次最大有氧性能 (TTE,VO2峰,6MW) 没有显著影响.
- 仅限于心血管疾病条件的分析也显示了对有氧性能指标的微不足道到微小的影响.
结论:
- 尽管在个别研究中发现了一些积极的结果,但分析表明,无机酸盐补充剂对CPMD的身体功能有微不足道的影响.
- 研究中的大量异质性和小样本大小可能有助于观察到缺乏显著的 ergogenic 效应.
- 需要采用强有力的方法进行进一步的研究,以澄清酸盐补充剂在这些人群中的作用.
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