在血中定量维他诺化物:药理动力学研究和分析方法
Alex B Speers1,2, Axel Lozano-Ortiz1,2,3, Amala Soumyanath1,2
1BENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR 97239, USA.
Nutrients
|November 27, 2024
概括
本综述总结了来自Withania somnifera (阿什瓦甘达) 的维他诺利德的血药理动力学. 它详细介绍了分析方法,并介绍了这些生物活性化合物的人类和动物研究结果.
科学领域:
- 药理学和药理动力学 药理学和药理动力学
- 植物化学 植物化学
- 分析化学 分析化学
背景情况:
- 维坦尼亚·索姆尼费拉 (Ashwagandha) 是一种阿育吠陀的草药,被认为有助于减轻压力和失眠.
- 维他诺化物,类固醇乳,是阿什瓦甘达研究的主要生物活性化合物.
- 了解维他诺化的血存在和药理动力学对于其治疗应用至关重要.
研究的目的:
- 审查目前关于阿什瓦甘达中维他诺化物的血药动力学知识.
- 总结用于在血中检测维他诺化物的分析方法.
- 巩固人类和动物研究中关于维他诺化吸收和代谢的发现.
主要方法:
- 对20项研究 (16项动物,4项人类) 的系统审查.
- 在血中量化分离的维他诺化物或阿什瓦甘达产品的研究分析.
- 通常使用的分析技术:逆相液态色谱与质谱学 (LC-MS) 结合.
主要成果:
- 维他诺利德的血度根据特定的化合物,剂量和注射途径有显著的变化.
- 动物研究报告了六种维他诺化物 (5.6-8410 ng/mL) 的Cmax范围.
- 人类研究详细介绍了四种维他诺化物的药物动力学参数,其Cmax在0.1-49.5 ng/mL之间.
结论:
- 阿什瓦甘达中的维他诺化物在服用后可在血中检测到.
- 不同的维他诺化的药物动力学概况存在显著的变化.
- 需要进一步的研究才能充分阐明这些化合物的体内行为.
关键词:
这种植物是Withhania somnifera.阿什瓦甘达 (Ashwagandha) 是一个液体色谱学 液体色谱学 液体色谱学质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量药物动力学 药物动力学在 A 里面与haferin A 相结合.与甲基化物一起使用.更多相关视频
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