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外源核酸通过AMPK途径调节能量代谢,缓解SAMP8小鼠的心脏衰老

Yuxiao Wu^1,2, Rui Liu^1,2, Chan Wei^1,2

¹Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.

|November 27, 2024

概括

外源核酸 (NTs) 通过增强组织结构,抗氧化能力和能量代谢,改善了小鼠的心脏衰老. 这表明NTs可能会减轻心血管衰老过程.

科学领域:

心血管研究研究心血管研究
生物老龄化生物老龄化
营养科学营养科学

背景情况:

心血管疾病 (CVD) 是导致死亡的主要原因,衰老是主要的危险因素.
核酸 (NTs) 对生物功能至关重要,特别是在衰老和营养缺乏期间.
外源性NTs对心脏衰老的具体影响仍然在很大程度上未被探索.

研究的目的:

研究外源核酸对心脏衰老的影响.
阐明核酸在心脏衰老中的作用的基本机制.

主要方法:

使用老化加速小鼠易受-8 (SAMP8) 的小鼠,分为控制,低剂量NTs和高剂量NTs组.
衰老加速小鼠耐药性1 (SAMR1) 的小鼠作为参考组.
在9个月的干预期后,分析了心脏组织.

主要成果:

核酸治疗改善了心脏组织形态,抗氧化能力,并减少了炎症.
高剂量的NT增强了心脏能量代谢,可能是通过AMPK通路激活.
有证据表明线粒体生物发生和TFAM蛋白表达的增加.

结论:

外源核酸在老化小鼠模型中对心脏组织产生有益影响.
核酸补充剂可能提供一种减轻心脏衰老过程的策略.

关键词:

在 AMPK 路径上.心脏衰老的心脏衰老能量代谢能量代谢外源的核酸是外源的

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