橄叶提取物补充剂改善绝经后症状:一个随机,双盲,安慰剂控制的平行研究在绝经后妇女
Maria Imperatrice1, Anissa Lasfar1,2, Colin A J van Kalkeren3
1BioActor BV, Gaetano Martinolaan 50, 6229 GS Maastricht, The Netherlands.
Nutrients
|November 27, 2024
概括
橄叶提取物 (OLE) 补充剂改善了绝经后妇女的绝经症状和骨矿物质密度. OLE还对甘油三水平和甘油三/HDL-C比率产生了积极的影响.
科学领域:
- 妇女健康 妇女健康
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 更年期显著影响女性的健康,导致各种症状和生理变化.
- 绝经后的女性经常经历生活质量下降的症状,如热和改变身体组成.
- 目前的研究寻求自然干预措施,以减轻更年期的健康影响.
研究的目的:
- 评估橄叶提取物 (OLE) 缓解绝经后症状的疗效.
- 评估OLE对绝经后妇女的身体组成,手握强度和血脂概况的影响.
- 在这个人口群体中调查OLE对骨矿物质密度 (BMD) 的影响.
主要方法:
- 一项随机,双盲,安慰剂控制的研究,涉及60名年龄在47-70岁的健康的绝经后妇女.
- 参与者接受了250毫克/天的OLE或安慰剂12周.
- 评估包括更年期特异性生活质量问卷 (MENQoL),热闪干扰量表 (HFI),DXA扫描身体组成和BMD,以及血清脂质概况分析.
主要成果:
- 在6周和12周后,与安慰剂相比,在OLE组观察到总体MENQoL得分的显著改善.
- 在OLE组中记录了右手臂的BMD显著增加.
- OLE补充剂导致甘油三 (TG) 度和TG/HDL-C比率显著降低.
结论:
- 十二周的每日OLE补充剂有效改善了绝经后症状和骨硬化.
- OLE对脂质配置文件产生了积极影响,特别是降低了TG和TG/HDL-C比率.
- 需要进一步的研究来探索OLE在绝经后妇女中所带来的益处的潜在机制.
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