人类牛奶中的"OMICS":专注于对骨质平衡的生物学影响
Ilaria Farella1, Gabriele D'Amato2, Andrea Orellana-Manzano3
1Department of Medicine and Surgery, LUM University, 70010 Casamassima, Italy.
Nutrients
|November 27, 2024
概括
人母乳成分显著影响婴儿骨发育. 母乳中的营养素,脂质和激素促进骨矿化和生长,通过各种生物途径影响骨健康.
科学领域:
- 营养科学 营养科学
- 儿科 儿科 儿科
- 生物化学 生物化学
背景情况:
- 人母乳 (HM) 是婴儿营养和生物活性化合物的重要来源.
- 奥米克技术为HM在婴儿骨发育中的作用提供了新的见解.
- 了解HM对骨健康的影响对于生命早期营养至关重要.
研究的目的:
- 审查HM成分对婴儿骨代谢和骨生长的影响.
- 探索蛋白质,脂质,碳水化合物,激素和微RNA在骨发育中的作用.
- 通过婴儿肠道微生物群,突出显示HM对骨健康的间接影响.
主要方法:
- 文献综述整合了蛋白质组学,代谢组学和转录组学的发现.
- 对特定的HM成分及其对骨细胞和通路的影响的研究分析.
- 检查与HM和骨健康有关的激素,microRNA和肠道微生物组的研究.
主要成果:
- 蛋白质 (素,乳清) 增强的吸收和骨质细胞的活性.
- 多可萨赫萨酸 (DHA) 调节炎症和骨质细胞功能.
- 人类牛奶寡糖 (HMO) 改善肠道健康和的生物可用性.
- 激素 (IGF-1,莱普丁,阿迪波内克丁) 影响婴儿的生长,身体组成和骨密度.
- 微RNAs (miRNAs) 调节脂肪生成和骨质稳定.
- HM促进婴儿肠道微生物群的平衡,有助于营养物质的吸收,促进骨的发育.
结论:
- 婴儿骨组件在支持婴儿骨健康方面发挥着多方面的作用.
- 需要进一步的综合研究和纵向研究来充分阐明这些复杂的关系.
- 优化母亲的饮食和HM成分有可能改善婴儿的骨健康.
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