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间歇性禁食对免疫参数和肠道炎症的影响

Eva Haasis¹, Anna Bettenburg¹, Axel Lorentz¹

¹Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, Germany.

|November 27, 2024

概括

间歇性禁食 (IF),包括交替禁食 (ADF) 和时间限制饮食 (TRE),在动物模型和健康人群中显示出抗炎作用. 这些禁食方法可以通过减少炎症和改变微生物群组成来改善肠道健康.

科学领域:

胃肠病学胃肠病学
营养科学营养科学
免疫学免疫学免疫学

背景情况:

间歇性禁食 (IF) 包含各种饮食模式,如交替禁食 (ADF) 和时间限制饮食 (TRE).
IF与疾病预防和管理有关,包括炎症性肠病 (IBD).
关于IF,特别是IBD患者的研究有限,因此需要对健康个体进行研究.

研究的目的:

审查现有的动物和人类研究对IF对肠道炎症的影响.
评估不同IF方法的抗炎作用和对微生物群组成的影响.

主要方法:

20项动物和人类研究的系统审查.
对大肠炎动物模型中ADF和TRE的研究分析.
由于IBD患者数据稀缺,在健康个体中包括FI (包括斋月禁食,TRE和ADF) 的人类研究.

主要成果:

动物研究:ADF和TRE改善了组织学评分,减少了炎症标志物和氧化应激,并调节了微生物群组成.
人类研究 (不包括斋月禁食):TRE和ADF表现出抗炎作用,显著降低C反应蛋白 (CRP) 水平和其他炎症标志物.
TRE还对健康个体的微生物群组成和时钟基因的昼夜振荡产生了积极的影响.

结论:

ADF和TRE具有抗炎性质,可能有利于肠道健康.
在健康人群中,TRE和ADF的疗效似乎与连续禁食时间的持续时间有关.
虽然动物研究表明,不论禁食时间有多长,都有益处,但需要进一步的研究,特别是在IBD患者身上.

关键词:

另行每天禁食一天.大肠炎是一种大肠炎.免疫参数免疫参数这是一种炎症炎症炎症炎症.断断续续的禁食是一种禁食.有时间限制的养.

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