在COVID-19感染期间胃肠道症状的益生菌疗法:随机,双盲,安慰剂控制,远程研究
Angela Horvath1,2, Rosa Haller1,2, Nicole Feldbacher1,2
1Division for Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8010 Graz, Austria.
这项研究调查了COVID-19患者在居家隔离期间的肠道微生物组. 虽然益生菌调节了微生物组,但在轻微的情况下,它们没有显著改变症状或便代谢组.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 胃肠道表现,包括腹,影响高达50%的SARS-CoV-2 (COVID-19) 患者.
- 益生菌正在被探索为潜在的治疗干预COVID-19相关的胃肠道症状.
研究的目的:
- 为了评估在家隔离的COVID-19患者的微生物组变化.
- 用远程远程医疗方法评估多种益生菌干预对肠道微生物群和症状的影响.
主要方法:
- 一项随机对照试验涉及30名COVID-19患者在家庭隔离中,接受多种益生菌或安慰剂30天.
- 通过在线调查和收集便样本进行微生物组和代谢学分析来远程监测呼吸道和胃肠道症状.
- 将患者数据与24名健康志愿者作为对照进行比较.
主要成果:
- 在研究期间,患者在呼吸道和胃肠道症状方面经历了显著的改善,无论他们是否使用益生菌.
- 与对照组相比,在COVID-19患者中观察到便微生物组合的显著变化 (p=0.002).
- 益生菌干预通过引入*Enterococcus faecium* W54显著调节微生物群β多样性 (p=0.001),但没有影响症状或代谢.
结论:
- 在家庭隔离中的轻度COVID-19病例与呼吸系统症状,胃肠道生活质量下降以及便微生物组和代谢组的改变有关.
- 虽然益生菌可以调节这些患者的肠道微生物群,但它们对症状和新陈代谢的临床影响需要进一步调查.
更多相关视频
08:53Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
12:12Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
Published on: February 8, 2016
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Drugs for Treatment of Constipation-Predominant IBS
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
What is Monogastric Digestion?
