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补充逃避保护FCoV在原型FIP病变中的病毒清除

Anne Hönl^1,2, Sandra Felten³, Katharina Erber²

¹LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany.

|November 27, 2024

概括

猫类传染性腹膜炎 (FIP) 在猫中涉及猫类冠状病毒 (FCoV) 逃避免疫系统. 受感染的巨细胞使用补体调节因子来保护自己免受补体系统的侵害,从而导致FIP的发病.

科学领域:

兽医免疫学兽医免疫学
猫类传染病猫类传染病
补充系统生物学补充系统生物学

背景情况:

猫传染性腹膜炎 (FIP) 是一种由猫冠状病毒 (FCoV) 引起的致命疾病.
猫的免疫系统,包括补体系统,在FIP期间无法清除FCoV.
在FIP发病过程中补充系统无效的机制尚不清楚.

研究的目的:

调查补充调节因子 (CRF) 在FIP病变发生中的作用.
在FIP病变中确定CD46和CD59的空间表达.
评估CRFs,补充激活 (C1q,C9) 和FCoV感染细胞之间的关系.

主要方法:

多重免疫组织化学用于分析31只患有FIP的猫的档案组织样本.
在FIP病变中评估了CD46,CD59,C1q和C9的空间表达.
评估了与FCoV感染细胞的局部化和接近病变的情况.

主要成果:

在FIP病变中,FCoV感染的巨细胞附近的CD46和CD59显著表达.
在FIP病变中,CRF表达明显较低,而与FCoV感染细胞的远端区域相比.
补充激活因子C1q和C9的表达在FIP病变中更高.

结论:

患有FIP的猫的FCoV感染的巨细胞利用CRFs的自和副表达.
CRFs保护FCoV感染的巨细胞免受补充介导的破坏.
这种免疫规避策略有助于FIP的致病性.

关键词:

在C1qq中,C1q为C1q.C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 C9 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD59 CD59 是一个在FIP中,FIP是FIP.互补系统是互补的系统.免疫逃避免疫逃避免疫组织化学免疫组织化学

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