长时间视觉唤起的潜在延迟在狗自然感染犬病毒的狗
Mary Gutiérrez1, Luis Delucchi1, Alejandro Bielli2
1Small Animals Medicine Unit, Department of Clinics & Veterinary Hospital, Clinical Neurology, Faculty of Veterinary, Universidad de la República (Udelar), Route 8 Km 18, Montevideo 13000, Uruguay.
Viruses
|November 27, 2024
概括
改变的视觉唤起潜能 (VEP) 表明狗 (CD) 的狗的神经损伤. 这一发现可能有助于在CD的亚临床阶段检测中枢神经系统疾病.
科学领域:
- 兽医神经学 兽医神经学
- 神经免疫学 神经免疫学
- 莫比利病毒研究研究
背景情况:
- 狗 (CD) 是一种严重的多系统病毒感染,由Morbillivirus引起.
- 神经性并发症,特别是脱髓性白内障,在犬病毒 (CDV) 感染中很常见.
- 狗和人类多发性硬化症 (MS) 在临床表现和病理生理学上存在相似之处.
研究的目的:
- 为了研究神经性犬病的狗视觉唤起潜能 (VEPs) 的异常.
- 评估VEP作为CDV感染狗的神经损伤早期诊断标记物的潜力.
主要方法:
- 视觉唤起的潜能 (VEP) 和电网红图 (ERG) 在头骨和脊柱水平上被记录.
- 对自然感染CDV的狗和健康的对照狗进行了记录.
主要成果:
- 患有CDV感染的狗显示VEP波延迟的双边增加 (N1,P1,N2,P2,N3) 没有振幅变化.
- 在感染犬和健康犬之间没有观察到电网红图 (ERG) 响应的显著差异.
结论:
- 改变的VEP反应表明在犬中存在亚临床神经损伤.
- 在狗中,VEP可以作为早期检测中枢神经传导障碍的宝贵工具.
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