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素tRNA修饰:将微生物组连接到转化体

Sherif Rashad^1,2

¹Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

BioEssays : news and reviews in molecular, cellular and developmental biology

|November 27, 2024

概括

素 (Q) 是一种tRNA修饰,对细胞应激反应至关重要,对神经退行性疾病和大脑健康有潜在的影响. 肠道细菌和饮食影响Q水平,影响mRNA翻译和疾病相关性.

科学领域:

分子生物学分子生物学
生物化学生物化学
微生物学微生物学

背景情况:

转移RNA (tRNA) 的修饰调节了mRNA在编码级的翻译.
素 (Q) 是一个在摇摆位置的关键tRNA修饰,由tRNA-瓜氨酸转糖酶 (TGT) 复合体合成.
队列 (Qbase) 被纳入GUN抗剂中,并来自肠道细菌和饮食.

研究的目的:

根据最近的文献和广泛的研究,回顾Queuosine (Q) 的生物学.
突出并讨论Q在神经精神疾病和癌症中的作用.
检查Q在细胞对氧化和线粒体应激反应中的影响.

主要方法:

文献综述综合了近四十年关于Queuosine (Q) 的研究.
分析Q在细胞应激反应,神经生物学和疾病病理学中的作用.
检查肠道微生物群,饮食和Q生物合成之间的相互作用.

主要成果:

素 (Q) 对于细胞对氧化和线粒体压力的反应至关重要.
已经证明在神经退行性疾病和大脑健康方面具有潜在的作用.
Q影响mRNA翻译动态和编码子选择.

结论:

素 (Q) 生物学提供了对肠道细菌对mRNA翻译调节和潜在的健康影响的见解.
进一步的研究是必要的,以充分了解Q的生物功能和疾病相关性,特别是在神经生物学.
关于Q参与神经精神疾病和癌症的调查需要继续进行.

关键词:

微生物组是一个微生物组.线粒体中的线粒体.神经退行性疾病的神经退行性疾病皇后是一个皇后.队列中没有任何东西.tRNA的修改 tRNA的改变

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