血可佩作为患有心力衰竭的儿童的预后标志物
Alyaa Ahdy Abdelaziz1, Ahmed Anwer Khattab1, Mohammed Hossam Abdelmaksoud1
1Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Indian pediatrics
|November 27, 2024
概括
血可佩有效预测心力衰竭 (HF) 的儿童的死亡率和不良结果. 升高的水平表明患有败血症,器官功能障碍的风险增加,在儿科HF患者中需要机械通风.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 生物标志物研究 生物标志物研究
- 关键护理医学 关键护理医学
背景情况:
- 儿童心力衰竭 (HF) 具有显著的死亡和发病风险.
- 早期识别高风险儿科HF患者对于及时干预至关重要.
- 需要新的生物标志物来改善儿科HF的风险分层.
研究的目的:
- 评估血可佩作为儿科心力衰竭 (HF) 中死亡率的预测因素.
- 评估血可佩与败血症,多器官功能障碍综合征 (MODS) 和机械通风需求等不良结果的关联.
- 为了确定血可佩水平与儿科重症监护室 (PICU) 停留时间之间的相关性.
主要方法:
- 一项涉及76名儿童 (1个月-16岁) 的诊断研究,因先天性或获得性心脏病而患有HF.
- 与65岁的年龄和性别匹配的健康儿童进行比较.
- 在入院后24小时内测量了平素的血水平;根据平素水平,HF患者被分为四分之一.
主要成果:
- 患有HF的儿童表现出明显高于健康对照组 (8.0 pmol/L) 的血中位数 (16.8 pmol/L) 的中位数.
- 较高的可佩四分位数与儿童死亡率III (PRISM III) 风险增加和内性得分相关.
- 在最高的科佩四分位数 (Q4) 中观察到血症,MODS和机械通风的发病率增加.
- 血可佩水平为35.5 pmol/L,表明72%的灵敏度和92.5%的特异性预测了儿科HF的死亡率.
结论:
- 血可佩作为一种有价值的新生物标志物,用于预测儿科心力衰竭的早期死亡率.
- 血上升的可佩水平与儿童高血压炎的严重程度和不良结果的增加有关.
- 素可能有助于识别患有HF的儿童有着预后不佳的高风险,指导临床管理.
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