下肢瘤病理骨折手术后的阿司匹林是否安全用于血栓预防?
Matthew S Chen1, Brandon S Gettleman2, Kevin C Liu1
1Keck School of Medicine of USC, Los Angeles, California, USA.
Journal of surgical oncology
|November 27, 2024
概括
与阿司匹林相比,埃诺沙巴林在下肢骨折的手术后显示出较高的静脉血栓栓塞 (VTE) 率. 需要进一步的研究来探索阿司匹林.
科学领域:
- 整形外科手术 整形外科手术
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 恶性病和骨科手术是静脉血栓塞栓症 (VTE) 的重要危险因素.
- 由于下肢瘤骨折而接受手术的患者面临高风险的VTE风险.
研究的目的:
- 为了比较下肢瘤骨折手术后接受恩奥沙巴林,阿皮克萨班,里瓦罗克萨班或阿司匹林 (ASA) 的患者的静脉瘤发作率.
主要方法:
- 利用Premier医疗保健数据库 (2015-2021) 来识别患有下肢瘤病理骨折的患者.
- 根据抗凝剂的使用创建了四个队列:阿司匹林 (ASA),阿皮克萨班,埃诺沙巴林和里瓦罗克萨班.
- 雇员倾向与以诺沙巴林队列作为比较对象匹配,分析人口统计学,医院因素,并发症和90天并发症.
主要成果:
- 与阿皮克萨班使用者相比,埃诺克萨巴林接受者的VTE总率显著更高 (p=0.008).
- 埃诺沙巴林的使用与阿司匹林 (ASA) (p=0.050) 相比,与更高的静脉瘤发病率有关.
结论:
- 与阿司匹林相比,埃诺沙巴林的使用可能与患有瘤下肢骨折的患者的术后静脉瘤发病率较高有关.
- 需要进行进一步的研究,以评估阿司匹林在选择的患有活跃恶性瘤且没有其他抗凝血指示的患者的VTE预防中的安全性.
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