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纳入癌症基因组测试的主流化:对接受度,有效性和影响的全面审查

Jennifer Berkman¹, Emily DeBortoli¹, Julia Steinberg²

¹Frazer Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Queensland, Australia.

Clinical genetics

|November 27, 2024

概括

通过遗传辅导员嵌入式 (GEM) 和高技能临床医生 (UPC) 模型将癌症基因组测试纳入主流是可行的和有益的. 该UPC模型显示经济可行性和积极的医生/患者结果,尽管需要更多的研究对GEM模型.

科学领域:

基因组医学是基因组医学.
癌症遗传学癌症遗传学
医疗保健提供模式医疗保健提供模式

背景情况:

有限的临床遗传学服务需要创新的模型来扩大基因组测试.
在癌症治疗中将基因组测试纳入主流是非常重要的,因为测试可用性越来越大.
遗传辅导员嵌入式 (GEM) 和高技能临床医生 (UPC) 模型是新兴的战略.

研究的目的:

评估将基因组测试纳入癌症护理中的可行性,可接受性和健康经济影响.
在瘤学环境中审查有关GEM和UPC模型的现有文献.
确定这些主流化方法的好处和局限性.

主要方法:

进行了2013-2023年PubMed文献的范围审查.
五种癌症类型的37篇相关文章被包括在完整的审查中.
提取了测试采用率,效率,经济影响和患者/医生结果的数据.

主要成果:

两种GEM和UPC模型都显示了高测试吸收率 (> * 主要发现是,将癌症基因组测试纳入主流是可行的和有益的. 该UPC模式在经济上是可行的,并提高了医生的知识,而患者的结果与标准护理相当. 需要对GEM模型和GEM与UPC之间的直接比较进行更多研究.
结论: [我们的结论是:

结论:

通过GEM和UPC模型将癌症基因组测试纳入主流是可行的,并提供了显著的好处.
该UPC模型证明了经济可行性,可接受的医生工作量和积极的患者结果.
需要进一步的研究来充分评估GEM模型的影响,并将GEM直接与UPC模型进行比较,包括相关的健康和护理角色.

关键词:

癌症癌症癌症癌症癌症遗传咨询遗传咨询遗传咨询基因检测基因检测是指基因检测.主流化是什么意思?照顾的模型.技能提升提高技能提高技能

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