根据生殖和荷尔蒙因素确定乳腺癌查的风险调整起始年龄和间隔
Tung Hoang1,2, Jeonghee Lee1, So-Youn Jung3
1Department of Cancer AI & Digital Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Republic of Korea.
International journal of cancer
|November 27, 2024
概括
这项研究建议基于生殖和荷尔蒙因素的个性化乳腺癌 (BC) 查年龄. 结果表明,延长乳房扫描查间隔超过五年仍然可以有效地检测出相当数量的BC病例.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 乳腺癌 (BC) 查策略旨在早期发现疾病.
- 基于风险因素和乳房扫描史的个性化查对于优化检测和资源分配至关重要.
- 韩国人口的特定生殖和荷尔蒙特征需要量身定制的BC查指南.
研究的目的:
- 根据生殖和荷尔蒙状况,确定乳腺癌查的风险调整起始年龄.
- 为了调查乳腺癌风险在阳性乳房扫描结果后,以告知查间隔.
- 为韩国人口提供个性化查策略的证据.
主要方法:
- 分析了2002年至2023年期间24,597名妇女的健康检查数据.
- 使用考克斯进展模型来评估BC风险.
- 根据10年累积风险的实现来定义风险适应的开始年龄,与一般人口中40岁女性相似.
主要成果:
- 妇女的生殖和荷尔蒙状况影响了她们的10年BC风险,将达到2.35%风险的年龄推移到8.55年之前或4.61年后.
- 在阴性乳房镜检查5年后,发生的BC病例在低风险和高风险组之间相似,与0至<2年内查的人相比.
- 该研究确定了潜在的基于风险的BC查起始年龄.
结论:
- 生殖和荷尔蒙因素可以指导个性化乳腺癌查开始年龄.
- 目前每两年进行一次乳房镜检查的间隔可以安全地延长到5年以后的某些妇女,而不会影响病例检测率.
- 这些发现支持在韩国开发适应风险的乳腺癌查计划.
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