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多omics的见解意味着在衰老中肠道结构和微生物组的重塑

Shaohua Chen^1,2, Chengbang Wang², Xiong Zou²

¹Department of Urology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China.

Frontiers in genetics

|November 27, 2024

概括

老龄化改变了肠道微生物群,增加了致病细菌,减少了有益的细菌. 这会影响肠道屏障功能和新陈代谢,导致炎症. 进一步的研究可能会确定与衰老相关的疾病的生物标志物.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
老年学是一门学科.

背景情况:

衰老会损害免疫功能,并导致慢性炎症 (炎症).
驱动炎症的机制尚未完全理解.

研究的目的:

研究与衰老相关的肠道微生物群和代谢变化.
阐明这些变化在发炎中的作用.

主要方法:

小鼠肠道微生物群的16S rRNA测序.
在人类样本中的验证.
评估肠道屏障功能和内毒素水平.
广泛针对的代谢学.

主要成果:

随着年龄的增长,病原细菌增加,有益细菌减少.
在老年人中,肠道屏障功能降低和循环内毒素升高.
改变胆酸代谢和粉/糖代谢途径的影响.

结论:

肠道微生物群失调和代谢变化与衰老和炎症有关.
这些发现为识别衰老生物标志物和治疗点提供了基础.

关键词:

老化的老化衰老的老化我们的肠道微生物群.炎症导致的炎症.肠道上皮细胞肠道上皮细胞代谢过程中的代谢.

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