梅奥内镜子评分在性结肠炎与并发性原发性硬化胆道炎的有限有效性
Pavel Wohl1, Alzbeta Krausova2, Petr Wohl3
1Department of Gastroenterology, Institute for Clinical and Experimental Medicine, Prague 14021, Czech Republic.
World journal of gastrointestinal endoscopy
|November 27, 2024
概括
梅奥内镜子评分 (MES) 对于评估与原发性硬化性胆道炎 (PSC) 结合的性结肠炎 (UC) 的准确性不如单独对UC的准确性. 组织学评估对于准确分类PSC-UC患者的炎症至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 炎症性肠道疾病研究研究
背景情况:
- 性结肠炎 (UC) 与原发性硬化性胆道炎 (PSC) 同时发生,形成一个独特的临床实体 (PSC-UC).
- 梅奥内镜子评分 (MES) 是UC活动的标准度量,但其在PSC-UC中的可靠性是不确定的.
研究的目的:
- 为了评估MES在UC和PSC-UC患者的准确性.
- 使用南希组织学指数 (NHI) 将MES与组织学评分进行比较.
主要方法:
- 在30名PSC-UC和29名UC患者的内镜中评估了MES.
- 从眼,直肠和终端骨的活检分析了NHI和炎症.
- 收集了包括血清学,便calprotectin和BMI在内的临床数据.
主要成果:
- 在UC患者中,MES和NHI一致 (MES等级2,NHI等级2).
- 在PSC-UC患者中,MES (0级) 和NHI (2级) 不同,88%的患者显示微观炎症,尽管MES低.
- 在11%的PSC-UC患者中,MES高估了炎症的严重程度.
结论:
- MES不足以检测PSC-UC中的微观炎症.
- 组织学评估应纳入PSC-UC和PSC的诊断和分级系统.
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