不调节的代谢物和参与骨关节炎的信号通路改变之间的相互作用:系统性审查
Atiqah Aziz1, Kavitha Ganesan Nathan1, Tunku Kamarul1
1Tissue Engineering Group, National Orthopaedic Centre of Excellence for Research and Learning, Department of Orthopaedic Surgery, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
本综述确定了关键的代谢生物标志物和参与骨关节炎 (OA) 的信号通路. 这些发现突出了这种复杂关节疾病的潜在诊断标志物和治疗点.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 系统生物学 系统生物学
背景情况:
- 骨关节炎 (OA) 是一种常见的退行性关节疾病,治疗选择有限.
- 代谢学通过揭示改变的代谢物和信号通路,提供了对OA的洞察.
- 对OA生物标志物的全面理解对于推进治疗策略至关重要.
研究的目的:
- 系统地识别与骨关节炎中失调的信号通路相关的代谢生物标志物.
- 分析来自各种生物样本的数据,包括体外,动物和人类研究.
- 提供OA中代谢物 - 途径相互作用的全面概述.
主要方法:
- 系统审查遵循系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 在PubMed,Scopus,Web of Science和谷歌学者中从2017年8月到2024年5月的文献搜索.
- 基于关键词的研究选择,重点关注代谢学,OA,生物标志物和信号通路.
主要成果:
- 确定了对OA炎症,氧化应激和能量代谢至关重要的失调代谢物 (氨基酸,脂质,碳水化合物).
- 突出了与炎症和软骨退化的相关的特定代谢物,如氨酸,氨酸和氨酸.
- 关键信号通路 (NF-κB,MAPK,Wnt/β-catenin,mTOR) 与OA中变化的代谢物水平相关.
结论:
- 揭示了OA中失调的代谢物和信号通路之间的复杂相互作用.
- 确定了潜在的新生物标志物和骨关节炎的治疗点.
- 强调需要进一步研究分子机制和治疗影响.
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