高压氧气治疗对SARS-CoV-2感染患者的影响:一项回顾性队列研究
Pingzhi Wang1, Zhengtao Wang1, Junyan Zhang2
1Department of Rehabilitation Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Journal of multidisciplinary healthcare
|November 27, 2024
概括
高压氧气疗法 (HBOT) 显著减少了COVID-19患者的治疗失败. 这种疗法有望改善结果,尽管注意到静脉血栓事件增加.
科学领域:
- 医学研究 医学研究
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 由于COVID-19存在重大风险,因此需要探索新的治疗策略.
- 高压氧气疗法 (HBOT) 已成为各种疾病的潜在辅助治疗方法.
研究的目的:
- 评估HBOT对感染SARS-CoV-2的患者的影响.
- 确定HBOT在减少COVID-19治疗失败事件中的有效性和安全性.
主要方法:
- 在720名COVID-19患者的回顾性队列研究中.
- 用于共变量平衡的治疗权重的反向概率 (IPTW).
- 主要终点:临床治疗失败 (死亡率,放弃,ICU转移).
主要成果:
- 在HBOT组 (27名患者) 的治疗失败率明显低于非HBOT组 (693名患者).
- 在HBOT组没有治疗失败,而非HBOT组有36例 (HR<0.001).
- 在HBOT组中观察到更高的静脉血栓事件发生率.
结论:
- 辅助HBOT显著降低了COVID-19患者治疗失败的风险.
- HBOT证明了令人满意的安全性,并有望改善COVID-19的结果.
- 淋巴细胞计数和HBOT与较低的失败风险相关;葡萄糖皮质类药物与更高的风险相关.
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