在山羊中评估Babesia ovis的致病性:对传播动态和宿主耐药性的影响
Sezayi Ozubek1, Mehmet Can Ulucesme1, Carlos E Suarez2,3
1Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, Elazig, Türkiye.
Frontiers in cellular and infection microbiology
|November 27, 2024
概括
与绵羊不同的是,山羊对Babesia ovis感染有抗性. 受感染的山羊不太可能维持传播的传播周期,这表明这种寄生虫的储备潜力有限.
科学领域:
- 兽医寄生虫学 兽医寄生虫学
- 传染性疾病 传染性疾病
- 动物健康 动物健康
背景情况:
- 贝贝西亚虫 (Babesia ovis) 导致绵羊的贝贝西病,导致绵羊的死亡率很高.
- 在山羊中,Babesia ovis的致病性和传播作用尚不清楚.
研究的目的:
- 调查山羊对Babesia ovis感染的易感性.
- 评估山羊作为Babesia ovis的储存库的潜力.
主要方法:
- 通过感染的血液和Rhipicephalus bursa,通过感染的血液和Rhipicephalus bursa,对未感染脏和脏切除的山羊进行试验感染Babesia ovis.
- 嵌套PCR被用于检测山羊中的Babesia ovis.
- 通过使用感染的进行了跨阶段和跨卵巢传播实验.
主要成果:
- 绵羊表现出严重的临床症状和高的寄生病,而山羊表现出没有显著临床表现的耐药性.
- 在两只没有脏的山羊身上通过嵌套PCR检测出Babesia ovis.
- 慢性感染的山羊并不是维持传播传播周期的重要来源.
结论:
- 与绵羊相比,山羊对Babesia ovis的敏感性不同.
- 没有脏的山羊作为Babesia ovis的存储库发挥了有限的作用.
- 进一步研究山羊乳病和宿主免疫力对于了解传播动态至关重要.
相关概念视频
01:28Infectious Diseases and Their Occurrence
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
01:26Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
01:28Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.