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Updated: Jun 6, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
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Induction and Validation of Cellular Senescence in Primary Human Cells

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关节骨折后细胞衰老的血标志物的持续升高:一个试点纵向研究

Eric J Lenze1, Ginger E Nicol1, George A Kuchel2

  • 1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.

Frontiers in aging
|November 27, 2024
PubMed
概括

关节骨折手术加速衰老,经过手术后增加的衰老相关分泌表型 (SASP) 指数得分表明. 这些分数最初上升,并且至少在12周内保持高,这表明需要进行干预.

关键词:
衰老的衰老 衰老的衰老生物老龄化的生物学.细胞衰老 细胞衰老部骨折 骨折 部骨折 部骨折与衰老相关的分泌表现型

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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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