儿童发病的风湿性疾病与肺部参与的细胞因子相关性
Hua Huang1, Fei Ding1, Chenxi Liu1
1Department of Rheumatology and Immunology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in pediatrics
|November 27, 2024
概括
升高的IL-6和IFN-γ水平与儿童类风湿性疾病 (RD) 的肺部参与有关. 这些细胞因子可能在RD病理生理学中发挥作用,有助于早期检测肺部并发症.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 有限的研究存在于细胞因子参与儿童发病的类风湿性疾病 (RD) 的肺部并发症.
- 了解这些炎症标志物对于管理具有呼吸道症状的RD患者至关重要.
研究的目的:
- 为了研究血清细胞因子水平和肺部参与新诊断的儿童发病的RD患者之间的关联.
- 确定潜在的生物标志物,用于在RD中早期检测肺部并发症.
主要方法:
- 在53名新诊断的RD患者和41名健康对照人群中测量了12种细胞因子的血清水平.
- 高分辨率计算机断层扫描 (HRCT) 和肺功能测试 (PFTs) 评估了肺部的参与.
- 进行了统计分析和ROC曲线研究,以评估细胞因子的诊断潜力.
主要成果:
- 与没有肺部干扰和对照组相比,肺部干扰患者的血清IL-6和IFN-γ水平显著更高.
- 肺部参与的RD中IL-6水平的中位数为19 pg/ml,而没有肺部参与的RD中为4.4 pg/ml.
- 中位数的IFN-γ水平是6.0 pg/ml在RD与肺部参与与5.0 pg/ml在RD没有肺部参与.
- IL-6 (AUC 0.782) 和IFN-γ (AUC 0.742) 显示了肺部参与的显著诊断潜力.
结论:
- IL-6和IFN-γ可能与儿童发病的肺部疾病的发展有关.
- IFN-γ (>5.42 pg/ml) 或IL-6 (>6.25 pg/ml) 的升高可能表明RD患者的肺部参与.
- 这些发现强调了特定细胞因子在RD相关的肺病理生理学中的作用.
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