基于药物化学的望远镜的thiophene及其衍生品:探索结构的见解,以发现可信的可用药物的线索
Shikha Thakur1, Devendra Kumar2, Shivani Jaiswal3
1Pharmaceutical Chemistry Laboratory, Department of Pharmacy, Birla Institute of Technology and Sciences Pilani Pilani Campus, Vidya Vihar Pilani - 333031 RJ India hemantrj@pilani.bits-pilani.ac.in.
RSC medicinal chemistry
|November 27, 2024
概括
含有蒂奥芬的药物越来越多地得到美国FDA的批准,其中26种药物在各种类别中获得批准. 本次审查强调了它们的多样化的生物活动和开发新药的潜力.
科学领域:
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 提奥芬是药物开发中的关键结构动机,在美国FDA批准的小分子中排名第四.
- 在过去的十年中,大约有七种含有蒂奥芬的新药获得了美国FDA的批准.
- 这突显了烯支架在当代制药研究中的重要性.
研究的目的:
- 审查美国FDA批准的药物,这些药物包含了硫环系统.
- 探索与烯衍生物相关的各种药理活动.
- 讨论结构生物信息学和结构-活性关系在基于硫的药物发现中的作用.
主要方法:
- 美国FDA批准的含有烯的药物的综合文献审查.
- 对提奥芬及其类似物报告的生物活性进行分析.
- 检查结构生物信息学和结构活动关系 (SAR) 研究.
主要成果:
- 总共有26种含有蒂奥芬核的药物已被美国FDA在多种药理学类别中批准.
- 烯衍生物具有广泛的生物活性,包括抗糖尿病,抗癌,抗炎症,抗和抗氧化特性.
- 该审查强调了结构生物信息学和SAR在理解药物疗效方面的重要性.
结论:
- 蒂奥芬支架是一种有价值的药,在经批准的药品中具有可靠的记录.
- 在生物信息学和SAR的指导下,对烯衍生物的进一步研究可以带来具有更好的疗效和安全概况的新疗法.
- 这一综述为未来利用烯核的药物开发工作提供了基础.
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