血清维生素D水平与与鼻多重症无控慢性鼻炎之间的关联
Nasir A Magboul1, Mohammed Alotaibi1, Fares Aldokhayel1
1Department of Otorhinolaryngology Head, and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ear, nose, & throat journal
|November 27, 2024
概括
低维生素D水平在慢性鼻炎与鼻多重症 (CRSwNP) 中很常见. 较低的维生素D与更严重的疾病有关,由较高的隆德-麦凯得分和鼻多等级表明.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 营养科学 营养科学
背景情况:
- 具有鼻多重症的慢性鼻鼻炎 (CRSwNP) 涉及2型炎症,通常由常规疗法管理不充分.
- 新兴研究表明,维生素D可能会影响过敏和炎症状况,包括CRSwNP.
研究的目的:
- 调查血清维生素D水平与CRSwNP严重程度之间的相关性.
- 为了确定CRSwNP患者中维生素D缺乏症的患病率.
- 根据内镜,成像和患者报告的结果评估维生素D水平.
主要方法:
- 血清维生素D水平测量了104名未经控制的CRSwNP等待手术的患者.
- 维生素D水平与隆德 - 麦凯 (LM) 评分,鼻腔结局测试-22 (SNOT-22),鼻息肉评分和氨酸细胞计数进行了比较.
主要成果:
- 维生素D水平与LM得分 (r = -0.210,P = 0.032) 和鼻息肉等级 (r = -0.264,P = 0.007) 有负相关性.
- 没有发现维生素D水平与SNOT-22得分或绝对乙酸细胞计数之间有显著的相关性.
- 平均维生素D水平为57.9 ± 31.2nmol/L.
结论:
- 在CRSwNP患者中,维生素D缺乏或不足很普遍.
- 较低的血清维生素D水平与增加的CRSwNP严重程度有关,由较高的LM得分和多等级表明.
- 这些发现支持维生素D状况下降和更严重的CRSwNP之间的联系.
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