年轻人突然心脏病死亡的趋势下降:20年全国性研究
在PubMed上查看摘要
概括
此摘要是机器生成的。年轻人突然心脏死亡 (SCD) 从2000年至2019年减少了49%. 虽然非医院心脏骤停的存活率有所改善,但未经证实的SCD率没有变化,需要新的预防策略.
科学领域
- 心脏病学
- 公共卫生
- 流行病学
背景情况
- 心血管疾病死亡率正在下降,但年轻人突然心脏病死亡的趋势尚未确立.
- 需要对1至35岁个体的SCD进行当代全国性数据.
- 了解与非医院性心脏骤停 (OHCA),遗传性心脏病以及可植入心脏转动器 (ICD) 使用相关的SCD趋势至关重要.
研究的目的
- 估计从2000年到2019年年轻人 (1-35岁) 中SCD的时间趋势.
- 将SCD趋势与OHCA模式的变化,遗传性心脏病诊断率和ICD植入率相关联.
- 确定改善SCD预防策略的潜在领域.
主要方法
- 在丹麦 (2000 - 2019) 进行的一项全国性队列研究包括所有年龄在 1 - 35 岁的人.
- 通过死亡证明,医疗档案和尸检报告来裁决SCD案件.
- 关于OHCA,遗传性心脏病和ICD的数据来自国家注册;发生率和时间趋势被计算.
主要成果
- 在年轻人中,SCD的总体发病率在20年内每年下降49% (每10万人年下降2.2%).
- 目击SCD率显著下降,而无目击SCD率保持不变,其比例增加了79%.
- 医院外心脏病停顿的生存率大幅提高 (3.9%至28%),遗传性心脏病诊断增加了10倍,ICD植入量增加了2倍.
结论
- 在过去的20年里, 年轻人突然心脏病死亡率显著下降.
- 随着SCD的下降,OHCA存活率的提高,遗传性心脏病诊断的增加以及ICD使用率的提高.
- 没有证实SCD率的变化凸显了新的预防方法的需要.
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