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最近的光反反应的发展催化了连续流下的Minisci类反应

Serena Pillitteri¹, Erik V Van der Eycken^1,2, Upendra K Sharma³

¹Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium.

Chemical communications (Cambridge, England)

|November 27, 2024

概括

米尼斯基反应使异环环的直接C-H功能化成为可能. 最近的连续流策略对于扩大这种重要的药物发现反应至关重要.

科学领域:

有机化学有机化学
药用化学医学化学
过程化学过程化学

背景情况:

迷尼斯基反应是直接C-H功能化异环的关键方法.
异环化合物是药物开发中的重要支架.
扩大Minisci反应对于制药生产至关重要.

研究的目的:

本文重点介绍了最近在扩大Minisci反应的进展.
主要目标是突出高效大规模合成的策略.
重点放在连续流程方法上.

主要方法:

关于Minisci反应扩大规模的最新文献的综述.
分析用于基于根的C-H功能化的连续流技术.
讨论影响反应效率和可预测性的因素.

主要成果:

连续流处理为Minisci反应扩展提供了显著的优势.
根和异环相互作用的可预测性在流量条件下保持.
最近的策略有助于高效和安全的大规模合成.

结论:

连续流是一种强大的方法,可以扩大Minisci反应的规模.
这种方法提高了Minisci反应在药物发现和开发中的实用性.
对于工业应用,建议进一步实施流体化学.

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