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相关概念视频

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model
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戈西佩丁通过调节COX2和ROS-JNK信号传递来缓解DSS诱导的结肠炎.

Hyeonjin Kim1, Eungyung Kim1, Lei Ma1

  • 1Department of Animal Science and Biotechnology, Research Institute for Innovative Animal Science, Kyungpook National University, Sangju-si, Gyeongsang buk-do, Republic of Korea, Daegu, South Korea.

Current pharmaceutical biotechnology
|November 27, 2024
PubMed
概括

戈西佩丁是一种天然的黄类化合物,在大肠炎模型中有效减少炎症和组织损伤. 这种化合物对治疗炎症性肠病 (IBD) 具有较少副作用的前景.

关键词:
这是一种抗炎症药物.DSS引起的结肠炎抗氧化剂是一种抗氧化剂.八传说中的八炎症性肠病是一种炎症性肠病.治疗潜力.治疗潜力.

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科学领域:

  • 胃肠道学和免疫学
  • 自然产品化学 自然产品化学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 炎症性肠病 (IBD) 是一种慢性胃肠道疾病,其全球发病率正在增加.
  • 目前的手术和药物等治疗方法都有局限性,包括侵入性和副作用.
  • 戈西佩丁 (Gossypetin) 是一种来自诸如黑树等植物的黄类化合物,已知具有抗氧化和抗癌性质,但其对IBD的影响尚不清楚.

研究的目的:

  • 在大肠炎模型中研究gossypetin的治疗潜力.
  • 评估gossypetin在缓解IBD症状和潜在的病理过程中的有效性.

主要方法:

  • 使用德克斯硫酸盐 (DSS) 诱导的大肠炎小鼠模型.
  • 使用疾病活动指数 (DAI) 评分和组织学分析评估治疗疗效.
  • 测量了通过qRT-PCR,免疫组织化学和西部斑块的炎症性细胞因子,超氧化物失调酶 (SOD),紧结标记物,COX-2和JNK信号.

主要成果:

  • 戈西佩丁治疗改善了DSS诱导的体重减轻和减少结肠损伤.
  • 戈西佩丁显著降低了DAI得分和结肠炎的组织学迹象.
  • 治疗增加了紧结表达,减少了炎症,反应性氧物种 (ROS),JNK信号传递和亡.

结论:

  • 戈西佩丁通过向ROS-JNK信号通路,显示出对大肠炎的显著治疗潜力.
  • 这种天然化合物可能为IBD治疗提供了一个有前途的替代方案,其疗效提高,副作用减少.
  • 突出了天然化合物的潜力,以开发针对炎症病的向疗法.