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黑人美国人的轴性脊柱关节炎:来自田纳西州谢尔比县五个中心的观察性研究

Krishna Kommineni¹, Iman Abutineh¹, Cathy Chapman¹

¹The University of Tennessee Health Service Center, Memphis.

ACR open rheumatology

|November 27, 2024

概括

黑人美国人占谢尔比县轴性脊柱关节炎 (axSpA) 病例的很大一部分,经常经历更严重的关节参与和先进的关节炎. 诊断延迟影响所有axSpA.患者.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
流行病学流行病学

背景情况:

轴性脊椎关节炎 (axSpA) 是一种免疫媒介疾病,影响轴性骨架.
了解axSpA在不同人群中的患病率和特征对于公平的医疗保健至关重要.

研究的目的:

确定谢尔比县黑人美国人axSpA的频率和临床特征.
调查该人口中的诊断延迟,疾病严重程度和健康差异.

主要方法:

来自五个谢尔比县中心的电子健康记录的回顾性观察研究.
通过ICD代码识别的axSpA患者;收集人口统计,临床特征和成像数据.
统计分析包括千平方,t测试和多变量回归来比较群体并确定疾病严重程度和诊断延迟的预测因素.

主要成果:

黑人美国人占确诊的axSpA患者的32%.
与白人患者相比,美国黑人患者的部参与率更高,C-反应蛋白升高,HLA-B27阳性率更低.
黑人美国人在X射线上 (OR 2.32) 患有晚期圣炎的几率增加了两倍,并且经历了显著的诊断延迟,白人患者也是如此.

结论:

黑人美国人在谢尔比县的axSpA患者群体中占有相当大的人口.
患有axSpA的黑人美国人患有更严重的关节疾病,更高的炎症标志物,以及更高的晚期圣炎的几率.
在axSpA患者中,显著的诊断延迟很普遍,不论种族或种族.

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