患者报告结果的性别差异和对外围的认知负担在非补偿性肝硬化和的门诊患者中
Florence Wong1, K Rajender Reddy2, Puneeta Tandon3
1Department of Medicine, Division of Gastroenterology & Hepatology, University of Toronto, Toronto, Ontario, Canada.
The American journal of gastroenterology
|November 27, 2024
概括
患有肝硬化和风的女性报告情感生活质量比男性更差,尽管日常功能相似. 这些发现突出了性别差异的体验的负担.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 生活质量研究 研究 生命质量研究
- 健康中的性别差异
背景情况:
- 瘤的负担显著影响了肝硬化患者的生活质量.
- 性别之间对炎的感知及其影响可能会有所不同.
- 了解这些基于性别的差异对于以患者为中心的护理至关重要.
研究的目的:
- 为了评估性别差异在感知的负担.
- 评估炎对与健康相关的生活质量 (HRQoL) 的影响,针对患有复发性或耐火性炎的男性和女性.
- 为了识别肝硬化患者中的活体验的差异.
主要方法:
- 预期招募患有肝硬化和需要大体积膜检查的大型膜的门诊患者.
- 收集人口统计数据,实验室结果,并发症,药物和脆弱性测量.
- 自我报告的HRQoL使用简单表格36和性别之间的Ascites问卷进行比较.
主要成果:
- 女性报告了更多的风相关症状和更高的风问卷得分 (66 ± 21 vs 60 ± 21;P = 0.001).
- 在女性中,抑郁症的发病率较高 (35%对22%;P = 0.0009),在简单表格36上精神功能得分较低.
- 尽管有情感上的差异,但女性和男性报告了类似的日常功能状态和体力活动水平.
结论:
- 与男性相比,患有肝硬化和风的女性经历了更差的情感生活质量.
- 在执行日常活动或从事休活动的能力方面,没有显著的性别差异.
- 患者报告的结果措施对于理解和解决肝硬化治疗中性别特异性挑战至关重要.
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