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多发性硬化症患者的自身免疫查小组:维也纳多发性硬化症数据库研究

Fabian Föttinger1,2, Nik Krajnc1,2, Katharina Riedl1,2

  • 1Department of Neurology, Medical University of Vienna, Vienna, Austria.

European journal of neurology
|November 27, 2024
PubMed
概括

自免疫查面板 (ASP) 在多发性硬化症 (MS) 患者中显示低血清阳性,类似于普通人群. 不建议常规使用ASP,除非有临床怀疑系统性自身免疫性疾病.

关键词:
自身免疫性疾病 自身免疫性疾病诊断技术和程序的诊断技术和程序.差异诊断是一种差异诊断.多发性硬化症多发性硬化症血清学的血清学

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科学领域:

  • 神经学 神经学
  • 免疫学 免疫学 免疫学
  • 临床诊断 临床诊断 临床诊断

背景情况:

  • 自免疫查面板 (ASP) 经常用于诊断多发性硬化症 (MS).
  • 关于ASP血清阳性在MS患者中的意义的数据有限.
  • 在MS诊断中常规ASP实施的实用性需要研究.

研究的目的:

  • 评估常规自身免疫查面板 (ASP) 在多发性硬化症 (MS) 诊断工作中的可行性.
  • 确定ASP血清阳性的意义在被诊断为MS的患者中.

主要方法:

  • 来自维也纳多发性硬化症数据库的2014-2021年间被诊断患有MS的212名患者的回顾性分析.
  • 纳入标准要求确认MS诊断和ASP的表现.
  • 分析包括患者人口统计,红旗症状的存在,补充水平和抗体子集.

主要成果:

  • 只有5.6%的MS患者出现了系统性自身免疫性疾病的红旗症状.
  • 对ASP的积极结果很少见,检测到的抗核抗体 (ANA) 占11.4%,可提取核抗体子集占4.7%.
  • 在少数患者中,ASP导致了其他自身免疫性疾病的诊断,具有较低的积极预测值 (例如,Sjögren综合征的4.9%).

结论:

  • 在多发性硬化症患者中,自身免疫查面板血清阳性率较低.
  • 在MS患者中的ASP结果与一般人群的预期范围相符.
  • 在没有系统性自身免疫疾病的特定临床怀疑的情况下,在MS诊断中不需要进行例行ASP测试.