更年期对多发性硬化症的影响
Cecilia Smith Simonsen1, Heidi Øyen Flemmen2, Line Broch1,3,4
1Department of Neurology, Vestre Viken Hospital Trust, Drammen, Norway.
European journal of neurology
|November 27, 2024
概括
更年期不会显著改变多发性硬化症 (MS) 疾病的进展. 研究表明,绝经前后的残疾或复发率没有差异,男性的进展速度比女性更快.
科学领域:
- 神经学 神经学
- 妇女健康 妇女健康
- 生殖内分泌学 生殖内分泌学
背景情况:
- 多发性硬化症 (MS) 影响了许多更年期前或更年期后的妇女,人口统计包括MS人口的三分之一.
- 更年期症状经常与MS症状重叠,使疾病管理和评估复杂化.
- 现有研究提出了关于更年期对MS残疾进展的影响的相互矛盾的证据.
研究的目的:
- 调查更年期与多发性硬化症疾病过程之间的关联.
- 确定更年期是否影响MS患者的残疾进展和复发率.
主要方法:
- 采用前性队列研究设计,随着时间的推移收集临床数据.
- 追溯数据收集包括自我报告的更年期年龄,吸烟史和平价.
- 分析对比了绝经前后妇女的疾病进展指标 (EDSS,ARR),以及与年龄相匹配的男性进行了比较.
主要成果:
- 在更年期前后的五年中,没有观察到扩大残疾状态量表 (EDSS) 进展或年度复发率 (ARR) 的显著差异.
- 与更年期后的男性相比,女性的EDSS进展速度较慢,尽管ARR没有显著差异.
- 在MS诊断之前更年期的出现与诊断的时间较长有关.
结论:
- 按EDSS和ARR测量,更年期似乎不会对多发性硬化症疾病进展产生负面影响.
- 绝经后女性的疾病进展比男性慢,这表明潜在的保护作用.
- 与MS发病和诊断相对而言,更年期的时间影响到诊断的时间.
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